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KMID : 0882419940470050711
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Korean Journal of Medicine
1994 Volume.47 No. 5 p.711 ~ p.716
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Nesidioblastosis of the Pancrease in Adult with Persistent Hyperinsulinemic Hypoglycemia
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구정완
정민영/김종목/김탁관/윤형진/박성진/이예봉/이정호/서정욱
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Abstract
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Nesidioblastosis, a condition characterized by diffuse islet cell hyperplasia arising from the ductal epithelium, is often associated with hyperinsulinemic hypoglycemia. This is the most common cause of persistent neonatal hypoglycemia and is
extremely
rare in adults.
A 38-year-old man had suffered from intermittent hypolycemic symptoms for 5 years, and had been relieved by carbohydrate ingestion. Plasma immunoreactive insulin levels and (I/G ratio were inappropriately high during prolonged fast.
Abdominal CT scan, angiography, and frozen section provided no evidence of a tumor.
Pathologic examination of the resected pancreas revealed irregularly sized islets and scattering of small endocrine cell clusters throughout the acinar tissue and ductuloinsular complex and distinct islet cell hypertrophy are present.
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KEYWORD
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